How do people run combat when one person is shooting at a person who is 1) unarmed; 2) not shooting back; or 3) doing some other kind of ranged attack, like a vampiric power? The rules only talk about Shooting vs. Shooting.
One option might be Shooting vs. Athletics (dodging), except that normal humans, even Jason Bourne, can't generally dodge bullets. Vampiric Speed might allow for that, but sometimes you need to shoot a regular old human target. Another option is Shooting vs. target's Hit Threshold, which is slightly higher if one has a high Athletics. That abstracts things pretty well, but is rather drastic.